Nephelometric monitoring growth of Candida albicans using BMG LABTECH’s NEPHELOstar® Plus
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چکیده
Econazole-nitrate (EC) and ciclopirox-olamine (CI) are well known antifungal agents suitable for the treatment of many mycotic infections. Previous studies showed that both dissolution properties and consequently microbiological activities of econazole, with very low water solubility (about 3 μg/mL at 25°C), can be improved by complexation with natural cyclodextrins, particularly with β-CD3-5. By increasing the water solubility of the drug it should be possible to improve its bioavailability, thus enabling improved oral or topical formulations.
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